Drug interactions
Glipizide + Sulfadiazine
Severity: Moderate
Glipizide and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials can potentiate sulfonylureas and cause hypoglycemia, sometimes severe. The risk is higher with renal impairment or in the elderly.
What this interaction means in plain words
Glipizide and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9 metabolism and protein binding displacement increase free glipizide.
What to do
Monitor blood glucose closely during co-therapy and reduce the glipizide dose if needed. Warn patients about hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Sulfadiazine?
MediHelp rates the interaction as moderate. Glipizide and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibacterials can potentiate sulfonylureas and cause hypoglycemia, sometimes severe. The risk is higher with renal impairment or in the elderly.
How serious is the interaction between Glipizide and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during co-therapy and reduce the glipizide dose if needed. Warn patients about hypoglycemia symptoms.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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