Drug interactions
Glipizide + Sulfamethoxypyridazine
Severity: Moderate
Glipizide and Sulfamethoxypyridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This long-acting sulfonamide may potentiate glipizide and cause hypoglycemia, as seen with other sulfonamides. Risk is greater in renal impairment.
What this interaction means in plain words
Glipizide and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely CYP2C9 inhibition and protein binding displacement, as with other sulfonamides.
What to do
Monitor blood glucose during co-therapy and lower the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Sulfamethoxypyridazine?
MediHelp rates the interaction as moderate. Glipizide and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This long-acting sulfonamide may potentiate glipizide and cause hypoglycemia, as seen with other sulfonamides. Risk is greater in renal impairment.
How serious is the interaction between Glipizide and Sulfamethoxypyridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during co-therapy and lower the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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