Drug interactions
Glipizide + Sulfasalazine
Severity: Moderate
Glipizide and Sulfasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine may enhance the glucose-lowering effect of sulfonylureas, with reports of hypoglycemia. The effect is generally modest.
What this interaction means in plain words
Glipizide and Sulfasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible protein binding displacement or CYP2C9 inhibition by the sulfonamide moiety; not well established.
What to do
Monitor blood glucose when sulfasalazine is started and adjust the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide and Sulfasalazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Sulfasalazine?
MediHelp rates the interaction as moderate. Glipizide and Sulfasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine may enhance the glucose-lowering effect of sulfonylureas, with reports of hypoglycemia. The effect is generally modest.
How serious is the interaction between Glipizide and Sulfasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when sulfasalazine is started and adjust the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
