Drug interactions
Glipizide + Willow bark
Severity: Minor
Glipizide and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylates. Large salicylate doses can potentiate sulfonylureas and cause hypoglycemia, although the amount from typical willow bark doses is small.
What this interaction means in plain words
Glipizide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylates can displace sulfonylureas from plasma protein and have intrinsic glucose-lowering effects.
What to do
Monitor blood glucose if high-dose willow bark is used regularly and reduce glipizide if hypoglycemia develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide
Frequently asked questions
Can I take Glipizide with Willow bark?
MediHelp rates the interaction as minor. Glipizide and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylates. Large salicylate doses can potentiate sulfonylureas and cause hypoglycemia, although the amount from typical willow bark doses is small.
How serious is the interaction between Glipizide and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if high-dose willow bark is used regularly and reduce glipizide if hypoglycemia develops.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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