Drug interactions
Glipizide-metformin + Iloperidone
Severity: Moderate
Glipizide-metformin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone, an atypical antipsychotic, can cause hyperglycemia and metabolic disturbance. This may reduce the effectiveness of glipizide and metformin and require changes to the antidiabetic regimen.
What this interaction means in plain words
Glipizide-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Atypical antipsychotics may impair insulin sensitivity and secretion, opposing the antidiabetic drugs pharmacodynamically.
What to do
Monitor fasting glucose and HbA1c at baseline and regularly during iloperidone therapy, and intensify antidiabetic treatment if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide-metformin and Iloperidone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Glipizide-metformin with Iloperidone?
MediHelp rates the interaction as moderate. Glipizide-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone, an atypical antipsychotic, can cause hyperglycemia and metabolic disturbance. This may reduce the effectiveness of glipizide and metformin and require changes to the antidiabetic regimen.
How serious is the interaction between Glipizide-metformin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c at baseline and regularly during iloperidone therapy, and intensify antidiabetic treatment if control worsens.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
