Drug interactions
Glipizide-metformin + Imidapril
Severity: Moderate
Glipizide-metformin and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors like imidapril can improve insulin sensitivity and enhance the hypoglycemic effect of glipizide and metformin. Renal function changes may also affect metformin clearance.
What this interaction means in plain words
Glipizide-metformin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Imidapril belongs to Cardiovascular.
Why it happens
ACE inhibition enhances insulin sensitivity and may reduce renal function, increasing metformin exposure.
What to do
Monitor blood glucose after starting the ACE inhibitor and check renal function periodically. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Glipizide-metformin with Imidapril?
MediHelp rates the interaction as moderate. Glipizide-metformin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors like imidapril can improve insulin sensitivity and enhance the hypoglycemic effect of glipizide and metformin. Renal function changes may also affect metformin clearance.
How serious is the interaction between Glipizide-metformin and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting the ACE inhibitor and check renal function periodically. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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