Drug interactions
Glipizide-metformin + Lornoxicam
Severity: Moderate
Glipizide-metformin and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the hypoglycemic effect of sulfonylureas such as glipizide, and lornoxicam is expected to behave similarly. NSAIDs may also impair renal function, which matters for metformin handling.
What this interaction means in plain words
Glipizide-metformin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Lornoxicam belongs to Musculoskeletal.
Why it happens
Possible displacement of sulfonylurea from plasma protein and inhibition of its metabolism, plus prostaglandin-mediated renal effects; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping the NSAID and watch renal function. Use the shortest effective NSAID course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Lornoxicam
Frequently asked questions
Can I take Glipizide-metformin with Lornoxicam?
MediHelp rates the interaction as moderate. Glipizide-metformin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may potentiate the hypoglycemic effect of sulfonylureas such as glipizide, and lornoxicam is expected to behave similarly. NSAIDs may also impair renal function, which matters for metformin handling.
How serious is the interaction between Glipizide-metformin and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and watch renal function. Use the shortest effective NSAID course.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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