Drug interactions
Glipizide-metformin + Lurasidone
Severity: Minor
Glipizide-metformin and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can worsen glucose control, though lurasidone has a relatively small metabolic effect compared with other agents in the class. Patients with diabetes may need closer glucose monitoring after starting it.
What this interaction means in plain words
Glipizide-metformin and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related insulin resistance and weight change may modestly raise blood glucose, opposing antidiabetic therapy.
What to do
Check fasting glucose and HbA1c at baseline and periodically, and adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Lurasidone?
MediHelp rates the interaction as minor. Glipizide-metformin and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics can worsen glucose control, though lurasidone has a relatively small metabolic effect compared with other agents in the class. Patients with diabetes may need closer glucose monitoring after starting it.
How serious is the interaction between Glipizide-metformin and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c at baseline and periodically, and adjust antidiabetic therapy if control worsens.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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