Drug interactions
Glipizide-metformin + Mefenamic acid
Severity: Moderate
Glipizide-metformin and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can potentiate sulfonylurea-induced hypoglycemia, and NSAID-related renal impairment may raise metformin exposure. The effect on glipizide is variable and generally modest.
What this interaction means in plain words
Glipizide-metformin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Proposed protein-binding displacement and reduced sulfonylurea metabolism, together with prostaglandin-dependent renal effects; mechanism not firmly established.
What to do
Monitor blood glucose after starting the NSAID and check renal function in at-risk patients. Reduce glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Glipizide-metformin with Mefenamic acid?
MediHelp rates the interaction as moderate. Glipizide-metformin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can potentiate sulfonylurea-induced hypoglycemia, and NSAID-related renal impairment may raise metformin exposure. The effect on glipizide is variable and generally modest.
How serious is the interaction between Glipizide-metformin and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting the NSAID and check renal function in at-risk patients. Reduce glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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