Drug interactions
Glipizide-metformin + Moxifloxacin
Severity: Moderate
Glipizide-metformin and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxifloxacin can cause hypoglycemia or hyperglycemia in diabetic patients, particularly those on sulfonylureas such as glipizide. Severe hypoglycemia has been reported with fluoroquinolones, although moxifloxacin is thought to carry a lower risk than some others.
What this interaction means in plain words
Glipizide-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones affect pancreatic beta-cell potassium channels and increase insulin secretion, adding to the sulfonylurea effect.
What to do
Increase blood glucose monitoring during the antibiotic course and counsel on hypoglycemia symptoms. Stop the quinolone and adjust therapy if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Moxifloxacin?
MediHelp rates the interaction as moderate. Glipizide-metformin and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxifloxacin can cause hypoglycemia or hyperglycemia in diabetic patients, particularly those on sulfonylureas such as glipizide. Severe hypoglycemia has been reported with fluoroquinolones, although moxifloxacin is thought to carry a lower risk than some others.
How serious is the interaction between Glipizide-metformin and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring during the antibiotic course and counsel on hypoglycemia symptoms. Stop the quinolone and adjust therapy if significant dysglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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