Drug interactions
Glipizide-metformin + Omeprazole
Severity: Minor
Glipizide-metformin and Omeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omeprazole may slightly increase glipizide exposure, but glipizide is cleared mainly via CYP2C9 and the effect is small. Clinically significant hypoglycemia is not expected.
What this interaction means in plain words
Glipizide-metformin and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Omeprazole belongs to Gastrointestinal Tract.
Why it happens
Possible weak inhibition of hepatic CYP-mediated glipizide metabolism.
What to do
No dose change is needed; monitor blood glucose when starting or stopping omeprazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Frequently asked questions
Can I take Glipizide-metformin with Omeprazole?
MediHelp rates the interaction as minor. Glipizide-metformin and Omeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omeprazole may slightly increase glipizide exposure, but glipizide is cleared mainly via CYP2C9 and the effect is small. Clinically significant hypoglycemia is not expected.
How serious is the interaction between Glipizide-metformin and Omeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood glucose when starting or stopping omeprazole.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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