Drug interactions
Glipizide-metformin + Peginterferon alfa 2b
Severity: Moderate
Glipizide-metformin and Peginterferon alfa 2b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferons can alter glycemic control, causing hyperglycemia or hypoglycemia and in some cases new-onset diabetes. Interferon-related suppression of CYP enzymes is possible but of uncertain relevance to glipizide.
What this interaction means in plain words
Glipizide-metformin and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Peginterferon alfa 2b belongs to Anti Virals.
Why it happens
Interferon effects on glucose metabolism and possible modulation of CYP2C9 activity; the mechanism is not clearly established.
What to do
Monitor blood glucose frequently during peginterferon therapy. Adjust antidiabetic doses based on readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Peginterferon alfa 2b
Frequently asked questions
Can I take Glipizide-metformin with Peginterferon alfa 2b?
MediHelp rates the interaction as moderate. Glipizide-metformin and Peginterferon alfa 2b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferons can alter glycemic control, causing hyperglycemia or hypoglycemia and in some cases new-onset diabetes. Interferon-related suppression of CYP enzymes is possible but of uncertain relevance to glipizide.
How serious is the interaction between Glipizide-metformin and Peginterferon alfa 2b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during peginterferon therapy. Adjust antidiabetic doses based on readings.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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