Drug interactions
Glipizide-metformin + Perphenazine
Severity: Moderate
Glipizide-metformin and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazine antipsychotics such as perphenazine can raise blood glucose and reduce the effectiveness of antidiabetic drugs. Control may improve again when the antipsychotic is withdrawn.
What this interaction means in plain words
Glipizide-metformin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Perphenazine belongs to Central Nervous System.
Why it happens
Phenothiazines can reduce insulin release and cause insulin resistance, opposing antidiabetic action.
What to do
Monitor blood glucose after starting or stopping perphenazine. Adjust antidiabetic doses as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Glipizide-metformin with Perphenazine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazine antipsychotics such as perphenazine can raise blood glucose and reduce the effectiveness of antidiabetic drugs. Control may improve again when the antipsychotic is withdrawn.
How serious is the interaction between Glipizide-metformin and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping perphenazine. Adjust antidiabetic doses as required.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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