Drug interactions
Glipizide-metformin + Phentermine
Severity: Minor
Glipizide-metformin and Phentermine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine-related weight loss and decreased food intake can lower glucose requirements, raising hypoglycemia risk with glipizide. Sympathomimetic effects may cause variable glucose changes.
What this interaction means in plain words
Glipizide-metformin and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Phentermine belongs to Central Nervous System.
Why it happens
Reduced caloric intake and sympathomimetic activity alter glycemic control.
What to do
Monitor glucose during weight loss and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Phentermine?
MediHelp rates the interaction as minor. Glipizide-metformin and Phentermine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phentermine-related weight loss and decreased food intake can lower glucose requirements, raising hypoglycemia risk with glipizide. Sympathomimetic effects may cause variable glucose changes.
How serious is the interaction between Glipizide-metformin and Phentermine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose during weight loss and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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