Drug interactions
Glipizide-metformin + Piroxicam
Severity: Moderate
Glipizide-metformin and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Piroxicam, like other NSAIDs, may enhance the hypoglycemic effect of glipizide. NSAID-related renal impairment can also increase metformin exposure.
What this interaction means in plain words
Glipizide-metformin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Piroxicam belongs to Musculoskeletal.
Why it happens
Possible displacement of glipizide from plasma proteins and reduced renal function; evidence is limited.
What to do
Monitor blood glucose and renal function with regular piroxicam use. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Frequently asked questions
Can I take Glipizide-metformin with Piroxicam?
MediHelp rates the interaction as moderate. Glipizide-metformin and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piroxicam, like other NSAIDs, may enhance the hypoglycemic effect of glipizide. NSAID-related renal impairment can also increase metformin exposure.
How serious is the interaction between Glipizide-metformin and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function with regular piroxicam use. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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