Drug interactions
Glipizide-metformin + Sirolimus
Severity: Moderate
Glipizide-metformin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus can cause hyperglycemia, insulin resistance and dyslipidemia, which can undermine the glucose control achieved with glipizide-metformin. Higher antidiabetic requirements may emerge.
What this interaction means in plain words
Glipizide-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Sirolimus belongs to Miscellaneous.
Why it happens
mTOR inhibition impairs insulin signaling and beta-cell function, producing pharmacodynamic antagonism.
What to do
Monitor glucose and HbA1c regularly. Intensify antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Sirolimus?
MediHelp rates the interaction as moderate. Glipizide-metformin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sirolimus can cause hyperglycemia, insulin resistance and dyslipidemia, which can undermine the glucose control achieved with glipizide-metformin. Higher antidiabetic requirements may emerge.
How serious is the interaction between Glipizide-metformin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c regularly. Intensify antidiabetic therapy as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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