Drug interactions
Glipizide-metformin + Tacrolimus
Severity: Moderate
Glipizide-metformin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can cause hyperglycemia and new-onset diabetes through toxic effects on pancreatic islets. This may reduce the effectiveness of glipizide-metformin.
What this interaction means in plain words
Glipizide-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Tacrolimus belongs to Miscellaneous.
Why it happens
Calcineurin inhibition impairs insulin secretion and promotes insulin resistance, antagonizing antidiabetic effects.
What to do
Monitor glucose and HbA1c routinely. Increase antidiabetic therapy as needed, and watch renal function because of metformin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Tacrolimus?
MediHelp rates the interaction as moderate. Glipizide-metformin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can cause hyperglycemia and new-onset diabetes through toxic effects on pancreatic islets. This may reduce the effectiveness of glipizide-metformin.
How serious is the interaction between Glipizide-metformin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and HbA1c routinely. Increase antidiabetic therapy as needed, and watch renal function because of metformin.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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