Drug interactions
Glipizide-metformin + Testosterone
Severity: Minor
Glipizide-metformin and Testosterone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Testosterone can improve insulin sensitivity, particularly in hypogonadal men, which may enhance the glucose-lowering effect of glipizide and metformin. Hypoglycemia is possible but usually modest.
What this interaction means in plain words
Glipizide-metformin and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Testosterone belongs to Endocrine.
Why it happens
Improved insulin sensitivity from androgen replacement adds to the effect of antidiabetic drugs.
What to do
Monitor blood glucose after starting or adjusting testosterone and reduce the sulfonylurea dose if low readings occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Frequently asked questions
Can I take Glipizide-metformin with Testosterone?
MediHelp rates the interaction as minor. Glipizide-metformin and Testosterone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Testosterone can improve insulin sensitivity, particularly in hypogonadal men, which may enhance the glucose-lowering effect of glipizide and metformin. Hypoglycemia is possible but usually modest.
How serious is the interaction between Glipizide-metformin and Testosterone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or adjusting testosterone and reduce the sulfonylurea dose if low readings occur.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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