Drug interactions
Glipizide-metformin + Tipranavir
Severity: Moderate
Glipizide-metformin and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, a protease inhibitor, may cause insulin resistance and hyperglycemia, reducing the effectiveness of glipizide and metformin. Tipranavir/ritonavir may also induce or inhibit enzymes, adding unpredictability.
What this interaction means in plain words
Glipizide-metformin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Tipranavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance and impaired glucose metabolism oppose antidiabetic effects.
What to do
Monitor blood glucose and HbA1c after starting or stopping tipranavir and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Tipranavir?
MediHelp rates the interaction as moderate. Glipizide-metformin and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir, a protease inhibitor, may cause insulin resistance and hyperglycemia, reducing the effectiveness of glipizide and metformin. Tipranavir/ritonavir may also induce or inhibit enzymes, adding unpredictability.
How serious is the interaction between Glipizide-metformin and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or stopping tipranavir and adjust antidiabetic therapy as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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