Drug interactions
Glipizide-metformin + Torsemide
Severity: Moderate
Glipizide-metformin and Torsemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics can raise blood glucose and may weaken glycemic control. Volume depletion and reduced renal function from diuretics can also raise metformin-related risk.
What this interaction means in plain words
Glipizide-metformin and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Torsemide belongs to Cardiovascular.
Why it happens
Loop diuretics may impair glucose tolerance via hypokalemia and reduced insulin secretion, opposing antidiabetic effects.
What to do
Monitor glucose, potassium and renal function. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Torsemide
Frequently asked questions
Can I take Glipizide-metformin with Torsemide?
MediHelp rates the interaction as moderate. Glipizide-metformin and Torsemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics can raise blood glucose and may weaken glycemic control. Volume depletion and reduced renal function from diuretics can also raise metformin-related risk.
How serious is the interaction between Glipizide-metformin and Torsemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose, potassium and renal function. Adjust antidiabetic therapy as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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