Drug interactions
Glipizide-metformin + Trimethoprim
Severity: Moderate
Glipizide-metformin and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim raises metformin plasma concentrations, which may increase metformin adverse effects and the risk of lactic acidosis, especially in renal impairment.
What this interaction means in plain words
Glipizide-metformin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Trimethoprim belongs to Anti Bacterial.
Why it happens
Trimethoprim inhibits renal tubular transporters OCT2 and MATE1, reducing metformin secretion.
What to do
Monitor renal function and glycemic response, and consider reducing the metformin dose in patients with reduced eGFR.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Trimethoprim
Frequently asked questions
Can I take Glipizide-metformin with Trimethoprim?
MediHelp rates the interaction as moderate. Glipizide-metformin and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim raises metformin plasma concentrations, which may increase metformin adverse effects and the risk of lactic acidosis, especially in renal impairment.
How serious is the interaction between Glipizide-metformin and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glycemic response, and consider reducing the metformin dose in patients with reduced eGFR.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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