Drug interactions
Glipizide-metformin + Voriconazole
Severity: Major
Glipizide-metformin and Voriconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole can raise glipizide levels, increasing the risk of prolonged or severe hypoglycemia. The effect has been seen with azole antifungals and sulfonylureas.
What this interaction means in plain words
Glipizide-metformin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glipizide-metformin belongs to Endocrine; Voriconazole belongs to Anti Fungals.
Why it happens
Voriconazole inhibits CYP2C9, reducing glipizide metabolism.
What to do
Monitor blood glucose closely and consider lowering the glipizide dose during voriconazole therapy. Warn the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glipizide-metformin
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Voriconazole?
MediHelp rates the interaction as major. Glipizide-metformin and Voriconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voriconazole can raise glipizide levels, increasing the risk of prolonged or severe hypoglycemia. The effect has been seen with azole antifungals and sulfonylureas.
How serious is the interaction between Glipizide-metformin and Voriconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and consider lowering the glipizide dose during voriconazole therapy. Warn the patient about hypoglycemia symptoms.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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