Drug interactions
Glucagon + Hyoscyamine spray
Severity: Moderate
Glucagon and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine given as a spray is absorbed systemically, so its antimuscarinic effect adds to glucagon-induced gut relaxation. This may worsen constipation, bloating or ileus in susceptible patients.
What this interaction means in plain words
Glucagon and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of gastrointestinal motility through glucagon smooth muscle relaxation and antimuscarinic blockade.
What to do
Monitor for abdominal distension, constipation and reduced bowel sounds. Avoid in patients with obstruction or severe dysmotility.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Glucagon and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine given as a spray is absorbed systemically, so its antimuscarinic effect adds to glucagon-induced gut relaxation. This may worsen constipation, bloating or ileus in susceptible patients.
How serious is the interaction between Glucagon and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal distension, constipation and reduced bowel sounds. Avoid in patients with obstruction or severe dysmotility.
What other medicines interact with Glucagon?
MediHelp also lists interactions of Glucagon with, for example, Atropine, Benztropine, Dicyclomine. The full list is on the Glucagon page.
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