Drug interactions
Glucagon + Insulin aspart-insulin aspart protamine
Severity: Minor
Glucagon and Insulin aspart-insulin aspart protamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and opposes insulin action, which is the basis for its use in treating severe hypoglycemia. Outside of rescue use, it can cause hyperglycemia and reduce insulin effect.
What this interaction means in plain words
Glucagon and Insulin aspart-insulin aspart protamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Insulin aspart-insulin aspart protamine belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucagon stimulates hepatic glycogenolysis and gluconeogenesis, opposing insulin.
What to do
Use glucagon for severe hypoglycemia as intended and monitor glucose afterward, giving oral carbohydrate once the patient can swallow. Reassess insulin dosing if glucagon is used repeatedly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as minor. Glucagon and Insulin aspart-insulin aspart protamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and opposes insulin action, which is the basis for its use in treating severe hypoglycemia. Outside of rescue use, it can cause hyperglycemia and reduce insulin effect.
How serious is the interaction between Glucagon and Insulin aspart-insulin aspart protamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use glucagon for severe hypoglycemia as intended and monitor glucose afterward, giving oral carbohydrate once the patient can swallow. Reassess insulin dosing if glucagon is used repeatedly.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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