Drug interactions
Glucagon + Insulin aspart
Severity: Minor
Glucagon and Insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and opposes the glucose-lowering action of insulin. This is the basis for its use in insulin-induced hypoglycemia, but it can also cause hyperglycemia afterward.
What this interaction means in plain words
Glucagon and Insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Insulin aspart belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: glucagon stimulates hepatic glycogenolysis and gluconeogenesis, opposing insulin.
What to do
Monitor blood glucose after glucagon use and adjust insulin as needed. Give oral carbohydrate once the patient can swallow to restore glycogen stores.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Other interactions of Insulin aspart
Frequently asked questions
Can I take Glucagon with Insulin aspart?
MediHelp rates the interaction as minor. Glucagon and Insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and opposes the glucose-lowering action of insulin. This is the basis for its use in insulin-induced hypoglycemia, but it can also cause hyperglycemia afterward.
How serious is the interaction between Glucagon and Insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after glucagon use and adjust insulin as needed. Give oral carbohydrate once the patient can swallow to restore glycogen stores.
What other medicines interact with Glucagon?
MediHelp also lists interactions of Glucagon with, for example, Atropine, Benztropine, Dicyclomine. The full list is on the Glucagon page.
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