Drug interactions
Glucagon + Insulin lispro
Severity: Minor
Glucagon and Insulin lispro: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and counteracts lispro, which is how it rescues insulin-induced hypoglycemia. Glucose may overshoot temporarily afterward.
What this interaction means in plain words
Glucagon and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glucagon belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through glucagon-stimulated hepatic glucose release.
What to do
Monitor blood glucose after glucagon use and adjust the next insulin doses. Follow with oral carbohydrate when feasible.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Other interactions of Insulin lispro
Frequently asked questions
Can I take Glucagon with Insulin lispro?
MediHelp rates the interaction as minor. Glucagon and Insulin lispro have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and counteracts lispro, which is how it rescues insulin-induced hypoglycemia. Glucose may overshoot temporarily afterward.
How serious is the interaction between Glucagon and Insulin lispro?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after glucagon use and adjust the next insulin doses. Follow with oral carbohydrate when feasible.
What other medicines interact with Glucagon?
MediHelp also lists interactions of Glucagon with, for example, Atropine, Benztropine, Dicyclomine. The full list is on the Glucagon page.
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