Drug interactions
Glucagon + Orphenadrine
Severity: Moderate
Glucagon and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has notable anticholinergic activity that slows gut motility, adding to the smooth muscle relaxing effect of glucagon. This can worsen constipation or ileus, and anticholinergic effects such as urinary retention may also be amplified in vulnerable patients.
What this interaction means in plain words
Glucagon and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of gastrointestinal motility through glucagon smooth muscle relaxation and anticholinergic activity.
What to do
Monitor for abdominal distension, constipation and reduced bowel sounds. Consider an alternative muscle relaxant in patients with dysmotility.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Orphenadrine?
MediHelp rates the interaction as moderate. Glucagon and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has notable anticholinergic activity that slows gut motility, adding to the smooth muscle relaxing effect of glucagon. This can worsen constipation or ileus, and anticholinergic effects such as urinary retention may also be amplified in vulnerable patients.
How serious is the interaction between Glucagon and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for abdominal distension, constipation and reduced bowel sounds. Consider an alternative muscle relaxant in patients with dysmotility.
What other medicines interact with Glucagon?
MediHelp also lists interactions of Glucagon with, for example, Atropine, Benztropine, Dicyclomine. The full list is on the Glucagon page.
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