Drug interactions
Glucagon + Phenindione
Severity: Moderate
Glucagon and Phenindione: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon has been reported to enhance the anticoagulant effect of oral vitamin K antagonists, possibly increasing INR and bleeding risk. The effect is mainly described with prolonged or repeated glucagon dosing and is unlikely with a single emergency dose.
What this interaction means in plain words
Glucagon and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; increased catabolism of vitamin K-dependent clotting factors has been proposed.
What to do
If glucagon is given repeatedly or over a prolonged period, monitor INR or prothrombin time and watch for bleeding. Adjust phenindione dose according to the result.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Phenindione?
MediHelp rates the interaction as moderate. Glucagon and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glucagon has been reported to enhance the anticoagulant effect of oral vitamin K antagonists, possibly increasing INR and bleeding risk. The effect is mainly described with prolonged or repeated glucagon dosing and is unlikely with a single emergency dose.
How serious is the interaction between Glucagon and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If glucagon is given repeatedly or over a prolonged period, monitor INR or prothrombin time and watch for bleeding. Adjust phenindione dose according to the result.
What other medicines interact with Glucagon?
MediHelp also lists interactions of Glucagon with, for example, Atropine, Benztropine, Dicyclomine. The full list is on the Glucagon page.
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