Drug interactions
Glucagon + Trihexyphenidyl
Severity: Moderate
Glucagon and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both anticholinergics and glucagon reduce gastrointestinal motility, so combined use can increase GI adverse effects such as constipation or ileus. Glucagon labeling notes this additive effect when used as a diagnostic aid.
What this interaction means in plain words
Glucagon and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glucagon belongs to Endocrine; Trihexyphenidyl belongs to Central Nervous System.
Why it happens
Additive inhibition of gastrointestinal motility by anticholinergic action and glucagon.
What to do
Avoid anticholinergics around glucagon use as a GI diagnostic aid, and monitor for constipation, abdominal distension and ileus otherwise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trihexyphenidyl
Other interactions of Glucagon
- Atropine + Glucagon Moderate
- Benztropine + Glucagon Moderate
- Dicyclomine + Glucagon Moderate
- Diphenoxylate-atropine + Glucagon Moderate
- Glucagon + Glycopyrrolate Moderate
- Glucagon + Glycopyrronium Moderate
Frequently asked questions
Can I take Glucagon with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Glucagon and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both anticholinergics and glucagon reduce gastrointestinal motility, so combined use can increase GI adverse effects such as constipation or ileus. Glucagon labeling notes this additive effect when used as a diagnostic aid.
How serious is the interaction between Glucagon and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid anticholinergics around glucagon use as a GI diagnostic aid, and monitor for constipation, abdominal distension and ileus otherwise.
What other medicines interact with Trihexyphenidyl?
MediHelp also lists interactions of Trihexyphenidyl with, for example, Orphenadrin, Oxybutynin, Scopolamine. The full list is on the Trihexyphenidyl page.
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