Drug interactions
Glucagon intranasal + Insulin degludec-insulin aspart
Severity: Minor
Glucagon intranasal and Insulin degludec-insulin aspart: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon raises blood glucose and opposes insulin; this is the intended effect when treating severe hypoglycemia in insulin-treated patients. Glucose may rise transiently and the response can be reduced when hepatic glycogen is depleted.
What this interaction means in plain words
Glucagon intranasal and Insulin degludec-insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucagon stimulates hepatic glycogenolysis and gluconeogenesis, pharmacologically opposing insulin.
What to do
Use glucagon for severe hypoglycemia as intended, follow with oral carbohydrate once able, and recheck glucose afterward.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin degludec-insulin aspart
- Chlorpropamide + Insulin degludec-insulin aspart Major
- Clozapine + Insulin degludec-insulin aspart Major
- Diazoxide + Insulin degludec-insulin aspart Major
- Ethanol + Insulin degludec-insulin aspart Major
- Insulin degludec-insulin aspart + Mecasermin Major
- Insulin degludec-insulin aspart + Pioglitazone Major
Frequently asked questions
Can I take Glucagon intranasal with Insulin degludec-insulin aspart?
MediHelp rates the interaction as minor. Glucagon intranasal and Insulin degludec-insulin aspart have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon raises blood glucose and opposes insulin; this is the intended effect when treating severe hypoglycemia in insulin-treated patients. Glucose may rise transiently and the response can be reduced when hepatic glycogen is depleted.
How serious is the interaction between Glucagon intranasal and Insulin degludec-insulin aspart?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use glucagon for severe hypoglycemia as intended, follow with oral carbohydrate once able, and recheck glucose afterward.
What other medicines interact with Insulin degludec-insulin aspart?
MediHelp also lists interactions of Insulin degludec-insulin aspart with, for example, Chlorpropamide, Clozapine, Diazoxide. The full list is on the Insulin degludec-insulin aspart page.
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