Drug interactions
Glucagon intranasal + Sotalol
Severity: Minor
Glucagon intranasal and Sotalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glucagon can transiently raise heart rate and blood pressure via catecholamine release. In patients on beta-blockers this response may be exaggerated for blood pressure (unopposed alpha effect) or blunted for heart rate.
What this interaction means in plain words
Glucagon intranasal and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Glucagon-induced catecholamine release interacts with beta-adrenergic blockade.
What to do
Monitor pulse and blood pressure after glucagon use; the effect is typically brief.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Frequently asked questions
Can I take Glucagon intranasal with Sotalol?
MediHelp rates the interaction as minor. Glucagon intranasal and Sotalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glucagon can transiently raise heart rate and blood pressure via catecholamine release. In patients on beta-blockers this response may be exaggerated for blood pressure (unopposed alpha effect) or blunted for heart rate.
How serious is the interaction between Glucagon intranasal and Sotalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pulse and blood pressure after glucagon use; the effect is typically brief.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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