Drug interactions
Glyburide + Hydrochlorothiazide-losartan
Severity: Minor
Glyburide and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and so may weaken the glucose-lowering effect of sulfonylureas. The effect is usually small at low hydrochlorothiazide doses but can be noticeable in patients with marginal control.
What this interaction means in plain words
Glyburide and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Thiazide-related hypokalemia and impaired insulin secretion and sensitivity oppose the antidiabetic action.
What to do
Monitor blood glucose and HbA1c after starting or changing the thiazide, and adjust the glyburide dose if control worsens. Keep potassium in the normal range.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Glyburide and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can raise blood glucose and so may weaken the glucose-lowering effect of sulfonylureas. The effect is usually small at low hydrochlorothiazide doses but can be noticeable in patients with marginal control.
How serious is the interaction between Glyburide and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or changing the thiazide, and adjust the glyburide dose if control worsens. Keep potassium in the normal range.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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