Drug interactions
Glyburide + Indomethacin
Severity: Moderate
Glyburide and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin may potentiate the hypoglycemic action of glyburide, and in some patients this can lead to clinically significant low blood glucose. The interaction is inconsistent but relevant in elderly patients and those with renal impairment.
What this interaction means in plain words
Glyburide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Indomethacin belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and prostaglandin effects on insulin secretion; indomethacin is not a strong CYP2C9 inhibitor, so metabolic inhibition is unlikely to be major.
What to do
Monitor blood glucose closely when indomethacin is started or stopped. Lower the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Indomethacin?
MediHelp rates the interaction as moderate. Glyburide and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin may potentiate the hypoglycemic action of glyburide, and in some patients this can lead to clinically significant low blood glucose. The interaction is inconsistent but relevant in elderly patients and those with renal impairment.
How serious is the interaction between Glyburide and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when indomethacin is started or stopped. Lower the glyburide dose if hypoglycemia occurs.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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