Drug interactions
Glyburide + Leniolisib
Severity: Moderate
Glyburide and Leniolisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, transporters involved in glyburide disposition. Glyburide exposure may rise, increasing hypoglycemia risk.
What this interaction means in plain words
Glyburide and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Leniolisib belongs to Miscellaneous.
Why it happens
Inhibition of BCRP and hepatic OATP uptake reduces glyburide clearance.
What to do
Monitor blood glucose after starting leniolisib. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Leniolisib
Frequently asked questions
Can I take Glyburide with Leniolisib?
MediHelp rates the interaction as moderate. Glyburide and Leniolisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Leniolisib inhibits BCRP, OATP1B1 and OATP1B3, transporters involved in glyburide disposition. Glyburide exposure may rise, increasing hypoglycemia risk.
How serious is the interaction between Glyburide and Leniolisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting leniolisib. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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