Drug interactions
Glyburide + Linezolid
Severity: Moderate
Glyburide and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been linked with hypoglycemia in patients using insulin or oral antidiabetic drugs, so glyburide's glucose-lowering effect may be amplified. Glyburide itself carries a notable hypoglycemia risk, especially in older adults or renal impairment.
What this interaction means in plain words
Glyburide and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
The mechanism is not established; MAO inhibition by linezolid may contribute to enhanced glucose lowering.
What to do
Monitor blood glucose frequently during linezolid therapy and reduce the glyburide dose if low readings occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Linezolid?
MediHelp rates the interaction as moderate. Glyburide and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been linked with hypoglycemia in patients using insulin or oral antidiabetic drugs, so glyburide's glucose-lowering effect may be amplified. Glyburide itself carries a notable hypoglycemia risk, especially in older adults or renal impairment.
How serious is the interaction between Glyburide and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during linezolid therapy and reduce the glyburide dose if low readings occur.
What other medicines interact with Linezolid?
MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.
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