Drug interactions
Glyburide + Metreleptin
Severity: Moderate
Glyburide and Metreleptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metreleptin improves insulin sensitivity and lowers glucose, which adds to the effect of insulin secretagogues like glyburide. Together they can cause hypoglycemia, which may be severe.
What this interaction means in plain words
Glyburide and Metreleptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Metreleptin belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering from improved insulin sensitivity plus enhanced insulin secretion.
What to do
Monitor blood glucose closely when starting metreleptin and consider reducing the glyburide dose preemptively. Adjust further according to glucose readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Metreleptin
Frequently asked questions
Can I take Glyburide with Metreleptin?
MediHelp rates the interaction as moderate. Glyburide and Metreleptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metreleptin improves insulin sensitivity and lowers glucose, which adds to the effect of insulin secretagogues like glyburide. Together they can cause hypoglycemia, which may be severe.
How serious is the interaction between Glyburide and Metreleptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting metreleptin and consider reducing the glyburide dose preemptively. Adjust further according to glucose readings.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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