Drug interactions
Glyburide + Nadolol
Severity: Moderate
Glyburide and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nonselective beta-blockers can blunt adrenergic warning signs of hypoglycemia such as tremor and palpitations, and may prolong recovery from low glucose. They can also modestly alter glycemic control. Sweating is usually preserved.
What this interaction means in plain words
Glyburide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Nadolol belongs to Cardiovascular.
Why it happens
Beta-adrenergic blockade masks sympathetic hypoglycemia symptoms and impairs glycogenolysis-mediated glucose recovery.
What to do
Monitor blood glucose more often and teach the patient that sweating may be the main warning sign. Consider a cardioselective beta-blocker if one is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Glyburide with Nadolol?
MediHelp rates the interaction as moderate. Glyburide and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nonselective beta-blockers can blunt adrenergic warning signs of hypoglycemia such as tremor and palpitations, and may prolong recovery from low glucose. They can also modestly alter glycemic control. Sweating is usually preserved.
How serious is the interaction between Glyburide and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and teach the patient that sweating may be the main warning sign. Consider a cardioselective beta-blocker if one is needed.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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