Drug interactions
Glyburide + Semaglutide
Severity: Moderate
Glyburide and Semaglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Semaglutide enhances glucose-dependent insulin secretion, and adding it to glyburide increases the risk of hypoglycemia. Reduced food intake from semaglutide's appetite effects can add to this risk.
What this interaction means in plain words
Glyburide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Semaglutide belongs to Endocrine.
Why it happens
Additive pharmacodynamic stimulation of insulin secretion by a GLP-1 receptor agonist and a sulfonylurea.
What to do
Consider lowering the glyburide dose when semaglutide is started. Monitor blood glucose, especially during dose escalation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Other interactions of Semaglutide
Frequently asked questions
Can I take Glyburide with Semaglutide?
MediHelp rates the interaction as moderate. Glyburide and Semaglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Semaglutide enhances glucose-dependent insulin secretion, and adding it to glyburide increases the risk of hypoglycemia. Reduced food intake from semaglutide's appetite effects can add to this risk.
How serious is the interaction between Glyburide and Semaglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the glyburide dose when semaglutide is started. Monitor blood glucose, especially during dose escalation.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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