Drug interactions
Glyburide + Simvastatin
Severity: Minor
Glyburide and Simvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide may inhibit OATP1B1-mediated hepatic uptake of simvastatin acid, which could modestly raise systemic statin exposure. The theoretical consequence is a higher risk of myopathy, but clinical evidence is limited and the combination is commonly used.
What this interaction means in plain words
Glyburide and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide belongs to Endocrine; Simvastatin belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1 hepatic uptake of simvastatin acid by glyburide.
What to do
No dose change is generally needed; advise the patient to report muscle pain or weakness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Simvastatin?
MediHelp rates the interaction as minor. Glyburide and Simvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glyburide may inhibit OATP1B1-mediated hepatic uptake of simvastatin acid, which could modestly raise systemic statin exposure. The theoretical consequence is a higher risk of myopathy, but clinical evidence is limited and the combination is commonly used.
How serious is the interaction between Glyburide and Simvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; advise the patient to report muscle pain or weakness.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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