Drug interactions
Glyburide + Sulindac
Severity: Moderate
Glyburide and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the glucose-lowering effect of glyburide and occasionally cause hypoglycemia. Patients with renal impairment or advanced age are more susceptible.
What this interaction means in plain words
Glyburide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma proteins and prostaglandin-related effects on insulin secretion; mechanism not firmly established.
What to do
Monitor blood glucose when sulindac is started or stopped and adjust the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Sulindac?
MediHelp rates the interaction as moderate. Glyburide and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the glucose-lowering effect of glyburide and occasionally cause hypoglycemia. Patients with renal impairment or advanced age are more susceptible.
How serious is the interaction between Glyburide and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when sulindac is started or stopped and adjust the glyburide dose if hypoglycemia occurs.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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