Drug interactions
Glyburide-metformin + Iloperidone
Severity: Moderate
Glyburide-metformin and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics such as iloperidone are associated with hyperglycemia and weight gain, which can worsen diabetes control. Higher antidiabetic doses may be needed.
What this interaction means in plain words
Glyburide-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Iloperidone belongs to Central Nervous System.
Why it happens
Antipsychotic-related insulin resistance and metabolic effects oppose the glucose-lowering action; the exact mechanism is not fully established.
What to do
Monitor fasting glucose and HbA1c after starting iloperidone and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Glyburide-metformin with Iloperidone?
MediHelp rates the interaction as moderate. Glyburide-metformin and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atypical antipsychotics such as iloperidone are associated with hyperglycemia and weight gain, which can worsen diabetes control. Higher antidiabetic doses may be needed.
How serious is the interaction between Glyburide-metformin and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting iloperidone and adjust the antidiabetic regimen as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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