Drug interactions
Glyburide-metformin + Imidapril
Severity: Moderate
Glyburide-metformin and Imidapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors such as imidapril can enhance insulin sensitivity and increase the risk of hypoglycemia with sulfonylureas. Renal effects of ACE inhibition may also increase metformin accumulation.
What this interaction means in plain words
Glyburide-metformin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Imidapril belongs to Cardiovascular.
Why it happens
Enhanced insulin sensitivity from ACE inhibition and possible reduced renal clearance of metformin.
What to do
Monitor blood glucose after starting imidapril or changing the dose, and check renal function periodically. Reduce the antidiabetic dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Imidapril
- Amiloride + Imidapril Major
- Eplerenone + Imidapril Major
- Imidapril + Lithium Major
- Imidapril + Pregabalin Major
- Imidapril + Spironolactone Major
- Imidapril + Triamterene Major
Frequently asked questions
Can I take Glyburide-metformin with Imidapril?
MediHelp rates the interaction as moderate. Glyburide-metformin and Imidapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors such as imidapril can enhance insulin sensitivity and increase the risk of hypoglycemia with sulfonylureas. Renal effects of ACE inhibition may also increase metformin accumulation.
How serious is the interaction between Glyburide-metformin and Imidapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting imidapril or changing the dose, and check renal function periodically. Reduce the antidiabetic dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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