Drug interactions
Glyburide-metformin + Insulin glargine
Severity: Moderate
Glyburide-metformin and Insulin glargine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining basal insulin with glyburide-metformin produces additive glucose lowering and raises the risk of hypoglycemia. The combination is commonly used but dose changes may be needed.
What this interaction means in plain words
Glyburide-metformin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Insulin glargine belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects of insulin, a sulfonylurea and metformin.
What to do
Monitor blood glucose closely when starting or adjusting therapy and reduce the sulfonylurea dose if hypoglycemia occurs. Educate the patient on hypoglycemia recognition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Insulin glargine
Frequently asked questions
Can I take Glyburide-metformin with Insulin glargine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Insulin glargine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining basal insulin with glyburide-metformin produces additive glucose lowering and raises the risk of hypoglycemia. The combination is commonly used but dose changes may be needed.
How serious is the interaction between Glyburide-metformin and Insulin glargine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting therapy and reduce the sulfonylurea dose if hypoglycemia occurs. Educate the patient on hypoglycemia recognition.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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