Drug interactions
Glyburide-metformin + Ivacaftor
Severity: Moderate
Glyburide-metformin and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor weakly inhibits P-glycoprotein and CYP3A4 and may modestly raise exposure to glyburide, which can intensify glucose lowering. Clinically significant hypoglycemia is possible but not well documented.
What this interaction means in plain words
Glyburide-metformin and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor and its metabolite inhibit P-glycoprotein and weakly inhibit CYP3A, potentially reducing glyburide efflux and clearance.
What to do
Monitor blood glucose when ivacaftor is started or stopped, and lower the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Glyburide-metformin with Ivacaftor?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor weakly inhibits P-glycoprotein and CYP3A4 and may modestly raise exposure to glyburide, which can intensify glucose lowering. Clinically significant hypoglycemia is possible but not well documented.
How serious is the interaction between Glyburide-metformin and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when ivacaftor is started or stopped, and lower the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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