Drug interactions
Glyburide-metformin + Lasmiditan
Severity: Minor
Glyburide-metformin and Lasmiditan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits BCRP in vitro, and glyburide is a BCRP substrate, so glyburide exposure could increase. The clinical relevance is uncertain, but it could heighten hypoglycemia risk.
What this interaction means in plain words
Glyburide-metformin and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan may inhibit intestinal BCRP efflux of glyburide, based on in vitro data.
What to do
No routine change is needed. Advise patients to report symptoms of hypoglycemia and check glucose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Glyburide-metformin with Lasmiditan?
MediHelp rates the interaction as minor. Glyburide-metformin and Lasmiditan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lasmiditan inhibits BCRP in vitro, and glyburide is a BCRP substrate, so glyburide exposure could increase. The clinical relevance is uncertain, but it could heighten hypoglycemia risk.
How serious is the interaction between Glyburide-metformin and Lasmiditan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise patients to report symptoms of hypoglycemia and check glucose if they occur.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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