Drug interactions
Glyburide-metformin + Letermovir
Severity: Moderate
Glyburide-metformin and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir inhibits OATP1B1/3 and CYP2C9/2C19-related pathways and may raise glyburide concentrations, increasing the risk of hypoglycemia. Labeling advises glucose monitoring with this combination.
What this interaction means in plain words
Glyburide-metformin and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Letermovir belongs to Anti Virals.
Why it happens
Letermovir inhibits hepatic OATP1B1/3 uptake transporters, which may increase glyburide exposure.
What to do
Monitor blood glucose frequently during and after letermovir therapy and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Glyburide-metformin with Letermovir?
MediHelp rates the interaction as moderate. Glyburide-metformin and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir inhibits OATP1B1/3 and CYP2C9/2C19-related pathways and may raise glyburide concentrations, increasing the risk of hypoglycemia. Labeling advises glucose monitoring with this combination.
How serious is the interaction between Glyburide-metformin and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently during and after letermovir therapy and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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