Drug interactions
Glyburide-metformin + Liraglutide
Severity: Moderate
Glyburide-metformin and Liraglutide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liraglutide combined with a sulfonylurea increases the risk of hypoglycemia, which can be severe. Metformin contributes little to this risk, so the glyburide component is the main concern.
What this interaction means in plain words
Glyburide-metformin and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Liraglutide belongs to Endocrine.
Why it happens
GLP-1 receptor activation enhances insulin secretion, adding to sulfonylurea-induced insulin release.
What to do
Consider reducing the glyburide dose when starting liraglutide. Monitor blood glucose and counsel on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Liraglutide
Frequently asked questions
Can I take Glyburide-metformin with Liraglutide?
MediHelp rates the interaction as moderate. Glyburide-metformin and Liraglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liraglutide combined with a sulfonylurea increases the risk of hypoglycemia, which can be severe. Metformin contributes little to this risk, so the glyburide component is the main concern.
How serious is the interaction between Glyburide-metformin and Liraglutide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glyburide dose when starting liraglutide. Monitor blood glucose and counsel on hypoglycemia symptoms.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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