Drug interactions
Glyburide-metformin + Lonafarnib
Severity: Minor
Glyburide-metformin and Lonafarnib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lonafarnib is a sensitive CYP3A substrate, and glyburide is only a weak and poorly established CYP3A inhibitor. A clinically meaningful rise in lonafarnib exposure is unlikely, and the mechanism cannot be reliably supported.
What this interaction means in plain words
Glyburide-metformin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Lonafarnib belongs to Miscellaneous.
Why it happens
Glyburide is not an established CYP3A inhibitor, so the mechanism is not well characterized.
What to do
No dose adjustment is needed. Monitor for lonafarnib adverse effects such as gastrointestinal toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Lonafarnib
- Alfuzosin + Lonafarnib Contraindicated
- Amobarbital + Lonafarnib Contraindicated
- Apalutamide + Lonafarnib Contraindicated
- Bosentan + Lonafarnib Contraindicated
- Carbamazepine + Lonafarnib Contraindicated
- Clarithromycin + Lonafarnib Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Lonafarnib?
MediHelp rates the interaction as minor. Glyburide-metformin and Lonafarnib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lonafarnib is a sensitive CYP3A substrate, and glyburide is only a weak and poorly established CYP3A inhibitor. A clinically meaningful rise in lonafarnib exposure is unlikely, and the mechanism cannot be reliably supported.
How serious is the interaction between Glyburide-metformin and Lonafarnib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for lonafarnib adverse effects such as gastrointestinal toxicity.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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