Drug interactions
Glyburide-metformin + Lurasidone
Severity: Minor
Glyburide-metformin and Lurasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atypical antipsychotics can affect glucose metabolism, and lurasidone may raise blood glucose, though its metabolic effect is relatively small. This can reduce control in diabetic patients.
What this interaction means in plain words
Glyburide-metformin and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Lurasidone belongs to Central Nervous System.
Why it happens
Antipsychotics can cause insulin resistance and impaired insulin secretion through receptor-mediated metabolic effects.
What to do
Check fasting glucose and HbA1c at baseline and periodically. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Lurasidone?
MediHelp rates the interaction as minor. Glyburide-metformin and Lurasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Atypical antipsychotics can affect glucose metabolism, and lurasidone may raise blood glucose, though its metabolic effect is relatively small. This can reduce control in diabetic patients.
How serious is the interaction between Glyburide-metformin and Lurasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check fasting glucose and HbA1c at baseline and periodically. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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