Drug interactions
Glyburide-metformin + Mefenamic acid
Severity: Moderate
Glyburide-metformin and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mefenamic acid is metabolized by and may inhibit CYP2C9, the main pathway of glyburide, and can raise glyburide levels. This may cause hypoglycemia, and NSAID-induced renal effects can also raise metformin exposure.
What this interaction means in plain words
Glyburide-metformin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Competition for CYP2C9 metabolism and protein-binding displacement increase glyburide exposure, and NSAIDs may reduce renal metformin clearance.
What to do
Monitor blood glucose and renal function while taking mefenamic acid and limit it to short courses. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Mefenamic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Frequently asked questions
Can I take Glyburide-metformin with Mefenamic acid?
MediHelp rates the interaction as moderate. Glyburide-metformin and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mefenamic acid is metabolized by and may inhibit CYP2C9, the main pathway of glyburide, and can raise glyburide levels. This may cause hypoglycemia, and NSAID-induced renal effects can also raise metformin exposure.
How serious is the interaction between Glyburide-metformin and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function while taking mefenamic acid and limit it to short courses. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
